Receptor Specificity of the Fibroblast Growth Factor Family
نویسندگان
چکیده
منابع مشابه
The fibroblast growth factor family.
Acidic and basic fibroblast growth factors are structurally related monomeric proteins which have been purified from a diverse set of vertebrate tissues. These prototype FGFs2 are mitogenic toward a broad spectrum of mesodermand ectoderm-derived cells and can also serve as trophic factors and as mediators of developmental pathways in a variety of in vitro and in vivo systems. Within the past 3 ...
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Heparin and heparan sulfate glycosaminoglycans (HSGAGs) mediate a wide variety of complex biological processes by specifically binding proteins and modulating their biological activity. One of the best studied model systems for protein-HSGAG interactions is the fibroblast growth factor (FGF) family of molecules, and recent observations have demonstrated that the specificity of a given FGF ligan...
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crouzon syndrome is a rare autosomal dominant premature cranyosynostosis, caused by fibroblast growth factor receptor 2 gene mutation on chromosome 10. the predominant skull and facial malformations with potential compromise airway make the crouzon syndrome a demanding issue for anesthesiologists and surgeons, required dynamic team work. in this report we describe a child, a known case of crouz...
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In this review, we propose a broader view of the role of the fibroblast growth factor (FGF) family in modulating brain function. We suggest that some of the FGF ligands together with the FGF receptors are altered in individuals with affective disorder and modulate emotionality in animal models. Thus, we propose that members of the FGF family may be genetic predisposing factors for anxiety, depr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m601252200